Aortic dissection (AD) is a life-threatening vascular condition with high morbidity and mortality rates. In AD, a tear in the intimal layer of the aorta leads the blood to flow within the vessel wall, resulting in two or more flow channels, the true - physiological - lumen (TL) and one or more false - pathological - lumina (FL), separated by an intimal flap (IF). The morphology of a dissected aorta is highly complex and patient-specific, oftentimes characterized by a tortuous FL interconnected with the TL via multiple IF tears. This complex environment results in abnormal hemodynamic forces (e.g. pressure and shear stresses) that drives the evolution of the disease. Currently, imaging techniques are unable to provide an accurate assessment of the in vivo hemodynamics. However, the combination of clinical images and computational fluid dynamics (CFD) can provide important prognostic insight and therefore support the clinical-decision making process of this life-threatening disease.