MRI Image Acquisition and Tumor Treatment
Researchers aimed to determine the frequency-dependent electric field distribution within a patient’s brain; for this they used co-registered post-gadolinium T1-weighted, T2 and MP RAGE images, together with pre-specified conductivity and relative permittivity values for the cerebral structures. Retrospective neuroimaging analysis of TTFields therapy in a 67-year-old female patient with recurrent glioblastoma in the posterior right frontal brain 6 months after the initial treatment with neurosurgical resection, cranial irradiation with concomitant daily temozolomide, and followed by adjuvant temozolomide. She then received both bevacizumab, infused at a dose of 10 mg/kg every 2 weeks, and TTFields therapy, with which she applied onto her shaved head continuously when possible. The placement of the transducer arrays was based on a personalized computer-generated layout, which is derived from MRI-based morphometric measurements of her head, tumor size, and tumor location. She continued both treatments for 24 months until another site of disease was detected in the lateral border of the right lateral ventricle.
