PrimeSim SPICE is a high-performance SPICE circuit simulator for analog, RF, and mixed-signal applications. PrimeSim SPICE offers a unique multi-core/multi-machine scaling and heterogeneous compute acceleration on GPU/CPU delivering faster runtime with sign-off accuracy. PrimeSim SPICE supports high-frequency noise analysis, efficient S-Parameter handling while offering advanced analysis capabilities for periodic and non-periodic time-domain and frequency-domain applications. PrimeSim SPICE is fully integrated with PrimeWave Design Environment, a newly architected design environment and waveform viewer that encapsulates analysis and display requirements that significantly improve productivity. PrimeSim SPICE is a key engine inside PrimeSim Reliability analysis, a set of comprehensive solutions (Fault simulation, Static Circuit Check, MOS Aging, IR/EM, Variation) that analyze the full spectrum of a product life cycle, from early-life to end-of-life.