Significant injuries can be caused by high voltage electrical shocks, which can result in cutaneous burns, irreversible tissue damage and even death. Finite Element (FE) modelling based on CT and cryosection images of a mouse has allowed researchers to virtually investigate tissue damage and its relation to Joule heating amounts and electric shocks. Simpleware software was used to segment scan images for export as robust FE meshes to COMSOL Multiphysics®, where thermal analysis of tissue damage was carried out. This study demonstrates the benefits of image-based modelling for accurately reconstructing experimental tests involving anatomical data.
The Catholic University of America: T. T. A. Nguyen • J. C. Ramella-Roman
Burn Center, Washington Medical Center: L. Moffat • J. Shupp
A male mouse body, including skin and several organs, was visualised in ScanIP from free online co-registered CT and cryosection images.
Semi-automated segmentation tools were used to obtain nine structures, including the heart, lungs, stomach, liver, kidneys, bladder, and testes. Boolean operations were also applied in ScanIP to aid segmentation, while filters were used to smooth surface structures. 3D editing tools were used to add four parts, including fat and muscle layers, aorta branches and electrodes to the model, with the aim of simulating preferential pathways and electrical damage.
The segmented data was volume meshed in Simpleware ScanIP+FE using the +FE Free meshing algorithm. A compound coarseness of minus 40 was selected to ensure a sufficient quality mesh, which was generated with conforming interfaces. The mesh contained 3,198,443 elements for all domains, with homogeneous material properties assigned to each organ.
Meshes were then exported to COMSOL Multiphysics® for voltage application and the simulation of bio-heat transfer.