Medtronic constructed and validated a subject-specific, four-chamber porcine heart model to investigate coupled electro-mechanical phenomena from in vivo data. The full workflow is briefly summarized:
- CT scan data of a domestic swine with an ablated AV node and Micra AV™ pacing device was segmented in Simpleware
software to identify the atria, and to create the ventricles at end diastole before meshing for simulation.
- The model was set up to investigate coupled electro-mechanical performance, including mechanical calibration with
experimentally recorded LV pressure-volume loop, and validation by comparing the surfaces of the left and right ventricle
from an in-silico model with in vivo CT scans.
- Validated model function was compared with simulations of AV block in the same subject
From this study, Medtronic were able to demonstrate that, in addition to interrupted flow, AV block causes elevated stress and
strain throughout the heart during diastole following the missed ventricular beat. More generally, the project validated the
electromechanical function of a four-chamber beating heart model to investigate pathological dysfunction and gain valuable insights into the heart.